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| Chinese herbal remedies affecting thrombosisand hemostasis: A review |
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| DOI：10.15806/j.issn.2311-8571.2014.0022 |
| KeyWord:Chinese herbs, thrombosis, endothelium, platelet |
| Author | Institution |
| Quan Liacd |
a.Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing , China
c.Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing , China
d.Key Laboratory of Stasis and Phlegm of State Administration of Traditional Chinese Medicine of China, Beijing , China |
| Jing-Yu Fanacd |
a.Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing , China
c.Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing , China
d.Key Laboratory of Stasis and Phlegm of State Administration of Traditional Chinese Medicine of China, Beijing , China |
| Jing-Yan Hanabcd |
a.Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing , China
b.Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing , China
c.Key Laboratory of Microcirculation, State Administration of Traditional Chinese Medicine of China, Beijing , China
d.Key Laboratory of Stasis and Phlegm of State Administration of Traditional Chinese Medicine of China, Beijing , China |
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| Abstract: |
| Acute coronary syndrome, stroke and other ischemic events continue to be the most common causes of mortality and morbidity in the
world, and their incidence is rapidly increasing in the developing nations. These cardiovascular disorders clinically manifest as acute
atherothrombotic events. Application of oral antiplatelet drugs is a milestone in the therapy of cardiovascular diseases. However, the limited
efficacy of these drugs in the setting of arterial thrombosis, their unfavorable side effects, cost-to-benefit issues and the drug resistance
phenomenon substantiate the need for the development of new and more efficacious antithrombotic drugs. In recent years, with the progress
in the study of the Chinese medicine pharmacology, many Chinese herbs and formulas, as well as active constituents have been reported to
possess not only effects on platelet aggregation and activation but also beneficial roles in vascular functions. Compared with currently used
antithrombotic agents, herb remedies exert antithrombotic effects in a multi-pathway and multi-target manner. This paper will cover the
progress in research on the ameliorating effects of herbal remedies on thrombosis, with focusing on their protection of vascular endothelial
cells and inhibition of platelet activation. |
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