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| Advancement in research of anti-cancer effects oftoad venom (ChanSu) and perspectives |
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| DOI：10.15806/j.issn.2311-8571.2014.0024 |
| KeyWord:ChanSu, Anti-cancer, Bufadienolides, Bufalin, Cardenolides |
| Author | Institution |
| Miao Liu |
Shanghai Research Center for Modernization of TCM, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. China |
| Li-Xing Feng |
Shanghai Research Center for Modernization of TCM, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. China |
| Li-Hong Hu |
Shanghai Research Center for Modernization of TCM, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P.R. China |
| Xuan Liu* |
Shanghai Research Center for Modernization of TCM, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,
501 Hai-ke Road, Shanghai , P.R. China. |
| De-An Guo* |
Shanghai Research Center for Modernization of TCM, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,
501 Hai-ke Road, Shanghai , P.R. China. |
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| Abstract: |
| Toad venom, called as ChanSu in China, is a widely used traditional Chinese medicine (TCM) whose active components are mainly
bufadienolides. ChanSu could exhibit cardiotonic, anti-microbial, anti-inflammatory and, most importantly, anti-cancer effects. In the present
review, reports about the in vitro, in vivo and clinical anti-cancer effects of ChanSu or its representative component, bufalin, were summarized.
And, reported anti-cancer mechanisms of cardenolides, structure analogues of bufadienolides, were also introduced. Based on the results got
from research of ChanSu/bufalin and the results from cardenolides, possible signal network related to the anti-cancer effects of ChanSu/bufalin
was predicted. Furthermore, future potential use of ChanSu in anti-cancer therapy was discussed. |
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