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| Development of High Performance LiquidChromatography and Mass Spectrometry: a Key Engineof TCM Modernization |
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| DOI：10.15806/j.issn.2311-8571.2015.0006 |
| KeyWord:TCM,High performance liquid chromatography, Mass spectrometry,Metabolomics, Active ingredients, Quality control |
| Author | Institution |
| Zheng-Xiang Zhang |
Agilent Technologies China Co.,Ltd.,No. 3,Wang Jing Bei Lu,Chao Yang District,Beijing ,P.R.China |
| Xue Qiao |
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing , China |
| Min Ye |
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing , China |
| Man-Yu Zhang |
Agilent Technologies China Co.,Ltd.,No. 3,Wang Jing Bei Lu,Chao Yang District,Beijing , P.R. China |
| Yue Song |
Agilent Technologies China Co.,Ltd.,No. 3,Wang Jing Bei Lu,Chao Yang District,Beijing , P.R. China |
| Tao Bo* |
Agilent Technologies China Co.,Ltd.,No. 3,Wang Jing Bei Lu,Chao Yang District,Beijing , P.R. China |
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| Abstract: |
| Traditional Chinese Medicine (TCM) has been popular for thousand years in prevention and treatment of chronic diseases synergistically with
Western medicine while producing mild healing effects and lower side effects. Although many TCMs have been proven effective by modern
pharmacological studies and clinical trials, their bioactive constituents and the remedial mechanisms are still not well understood. Researchers
have made great efforts to explore the real theory of TCM for many years with different strategies. Development of high performance liquid
chromatography (HPLC) and mass spectrometry within recent decade can provide scientists with robust technologies for disclosing the
mysterious mask of TCM. In this paper, important innovations of HPLC and mass spectrometry are reviewed in the application of TCM
analysis from single compound identification to metabolomic strategy. |
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