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| New Insights into the Molecular Basis of KidneyGoverning Bone Theory |
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| DOI：10.15806/j.issn.2311-8571.2015.0011 |
| KeyWord:Osteoporosis, Kidney governing bone theory, Tonifying kidney prescriptions/herbs, Bone homeostasis, Effective components,Osteoclast, Osteoblast |
| Author | Institution |
| Dong-feng Zhaoab |
a.Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.b.Research Institute of Spine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. |
| Yong-jian Zhaoab |
a.Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.b.Research Institute of Spine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. |
| Cheng-long Wangab |
a.Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.b.Research Institute of Spine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. |
| Yan-ping Yangab* |
a.Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.b.Research Institute of Spine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. |
| Yong-jun Wangab* |
a.Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.b.Research Institute of Spine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. |
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| Abstract: |
| Kidney governing bone theory plays an important role in treating bone metabolic disease such as osteoporosis, and many tonifying kidney
prescriptions/herbs are widely used in Traditional Chinese Medicine (TCM). However, the exact biological basis of kidney governing bone
theory in the context of new advances in biology is still not fully established. In this paper, the content of kidney governing bone theory in
biology has been fully demonstrated from different aspects. We first propose that bone and kidney mutually affect each other in pathology and
physiology, particularly through homeostasis of calcium, phosphorus and fibroblast growth factor-23(FGF-23). Next, we identify that tonifying
kidney prescriptions/herbs exert bone protective effects, thus treating osteoporosis by regulating bone formation and bone resorption.
Furthermore, the exact molecular mechanisms of tonifying kidney prescriptions, herbs and their effective components in treating osteoporosis
have been systematically reviewed. Finally, we come into the conclusion that kidney regulating bone mineral homeostasis, bone protective
effects of tonifying kidney herbs and regulatory effects on bone homeostasis are all the manifestations of kidney governing bone theory.
Therefore, the new insights into kidney governing bone theory in biology will promote the development of clinical practices, and drugs
discovery in treating osteoporosis. |
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