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| Metabolomics Analysis of Health Functions of PhysalisPubescens L. using by Ultra-performance LiquidChromatography/Electrospray Ionization QuadrupleTime-of-Flight Mass Spectrometry |
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| DOI：10.15806/j.issn.2311-8571.2015.0015 |
| KeyWord:Metabolomics, Physalis pubescens L, antioxidant, anti-fatigue, metabolic pathway, biomarkers |
| Author | Institution |
| Hang Chu |
National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin , China |
| Hui Sun |
National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin , China |
| Guang-Li Yan |
National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin , China |
| Ai-Hua Zhang |
National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin , China |
| Chang Liu |
National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin , China |
| Hui Dong |
National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin , China |
| Xiang-Cai Meng |
National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin , China |
| Xi-Jun Wang* |
National TCM Key Laboratory of Serum Pharmacochemistry Laboratory of Metabolomics and Chinmedomics,
Department of Pharmaceutical Analysis Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin , China. |
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| Abstract: |
| Herbal medicines may benefit from metabolomics studies, and applying metabolomics may provide answers about which herbal interventions
may be effective for individuals, which metabolic processes are triggered, and the subsequent chemical pathways of activity. Physalis pubescens
L (PPL) is an herbal fruit for one year living plant and has been developed into healthy function’s food. However, the mechanisms of health
functions are still unclear. To comprehensively and holistically assess its anti-fatigue and antioxidant effects, a novel integrative metabolomics
approach was applied. In this study, we present metabolomics analysis applying ultra performance liquid chromatography coupled to
quadrupole with time-of-flight mass spectrometry (UPLC-Q/TOF-MS) to determine metabolite alterations after oral administration PPL to
rats. Fifteen metabolites in urine were identified as potential biomarkers. Pattern analysis of the UPLC-Q/TOF-MS data disclosed that PPL
could relieve fatigue rats by ameliorating the disturbance in amino acids metabolism and energy metabolism, alleviating the oxidative stress
from reactive oxygen species and the inflammatory damage, and recovering the destructed regulation. Based on these results, we demonstrated
that PPL is a promising source of natural anti-fatigue and antioxidants material for use in functional foods and medicines. |
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