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| Fluvastatin and the Breast Cancer Risk: A Meta-analysis ofObservational Studies |
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| DOI：10.15806/j.issn.2311-8571.2015.0025 |
| KeyWord:Fluvastatin, Breast cancer, Meta-analysis |
| Author | Institution |
| Dong-Mei Liua |
a.Oncology Department of Yulin First Hospital, Second Affiliated Hospital of Yanan University, Yulin Shaanxi, , PR China |
| Jian Zhangb# |
b.Cardiology Department of Yulin First Hospital, Second Affiliated Hospital of Yanan University, Yulin Shaanxi, , PR China |
| Wei Zhangc |
c.Pharmacy Department of Yulin First Hospital, Second Affiliated Hospital of Yanan University, Yulin Shaanxi, , PR China |
| James Lud |
d.Foreign languages institute of Yulin university, Yulin Shannxi, , PR China |
| Jian-Lun Hanb |
b.Cardiology Department of Yulin First Hospital, Second Affiliated Hospital of Yanan University, Yulin Shaanxi, , PR China |
| Guang-Jun Haoa* |
a.Oncology Department of Yulin First Hospital, Second Affiliated Hospital of Yanan University, Yulin Shaanxi, , PR China |
| Sheng-Ming Yeb |
b.Cardiology Department of Yulin First Hospital, Second Affiliated Hospital of Yanan University, Yulin Shaanxi, , PR China |
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| Abstract: |
| Multiple studies have investigated the associations between fluvatatin and the risk of breast cancer (BC), but their results were conflicting. A
meta-analysis of observational studies published regarding this subject was conducted in the present study. It aims to estimate the associations
between fluvastatin use and the risk of BC. Pubmed and chinese national knowledge infrastructure (CNKI) database was searched up to
January, 2015 to identify eligible observational studies, and the Newcastle-Ottawa Scale (NOS) was used to assess quality of the studies. Pooled
relative risk (RR) estimates and 95% confidence intervals (CIs) were calculated (fixed effect model: Mantel-Haenszel). Heterogeneities were
evaluated before the calculation. A sensitivity analysis was also conducted. In total, four studies contributed to the analysis. Overall, fluvastatin
use negatively correlated with BC risk (RR = 0.74, 95 % CI = 0.58, 0.95). In conclusion, fluvastatin use may reduce the risk of BC, but more
research is needed to confirm this finding. |
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