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| Pathophysiological Characteristics of Phlegm-stasisCementation Syndrome in Coronary Heart Disease:a Review and Update |
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| DOI：10.15806/j.issn.2311-8571.2015.0027 |
| KeyWord:pathophysiological characteristics, phlegm-stasis cementation syndrome, coronary heart disease, review
Received 5 August 2015 Accept 29 October 2015 |
| Author | Institution |
| Jian-Xun Rena |
a.Beijing Key Laboratory of Chinese Materia Pharmacology, Beijing , China |
| Dennis Changb |
b.National Institute of Complementary Medicine, University of Western Sydney, Sydney, Australia |
| Jian-Xun Liua* |
a.Beijing Key Laboratory of Chinese Materia Pharmacology, Beijing , China |
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| Abstract: |
| The pathophysiological characteristics of Phlegm-stasis Cementation Syndrome in Coronary Heart Disease (CHD) has been summarized in
this article. According to epidemiological investigations, phlegm-stasis cementation syndrome has become a dominant syndrome in CHD
along with the improvement in living and dietary condition. The interaction between blood stasis and phlegm turbidity that is called Phlegmstasis
Cementation Syndrome exists in CHD and other diseases. The bridge linked blood stasis and phlegm turbidity lies in the adversely
effects of lipid metabolism disorder on platelet activation, vascular function and hemorheology indexes. Lipid metabolism disorder also can
induce persistent inflammation including monocyte/macrophage activation and oxidative stress. Inflammation also is an important
stimulating factor for atherosclerosis and the biology that underlies the complications of CHD, which belonged to the concept of “toxin” in
Traditional Chinese medicines (TCM). On the other hand, the important function of inflammatory process on abnormal hemorheology,
platelet activation and vascular dysfunction can be used to elucidate the basic pathogenetic condition of the toxin inducing blood stasis in
TCM. Therefore, it is this pathological process that can be used to address the basic pathogenetic theory of phlegm turbidity inducing the
symptom of toxin and blood stasis, and subsequently phlegm-stasis cementation in TCM. We deduced that lipid metabolic disturbance,
inflammation activation, vascular dyfunction and hemorheological disorders could be as pathophysiological characteristics of Phlegm-stasis
cementation syndrome. |
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