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| Pharmacokinetics Applications of TraditionalChinese Medicines |
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| DOI：10.15806/j.issn.2311-8571.2015.0030 |
| KeyWord:Traditional Chinese medicine, Pharmacokinetics, Drug discovery, Active constituents |
| Author | Institution |
| Qiu-Ju Li |
National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin , China |
| Ai-Hua Zhang |
National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin , China |
| Hui Sun |
National TCM Key Lab of Serum Pharmacochemistry, Key Laboratory of Metabolomics and Chinmedomics, Department of Pharmaceutical Analysis,
Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin , China |
| Xi-Jun Wang* |
National TCM Key Laboratory of Serum Pharmacochemistry, Laboratory of Metabolomics and Chinmedomics,
Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin , China |
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| Abstract: |
| Traditional Chinese medicine (TCM) has been widely used in many oriental countries for thousands of years and played an indispensable
role in the prevention and treatment of diseases, especially the complicated and chronic ones. It is a very complex mixture containing
hundreds or thousands of different components. Pharmacokinetic study on active constituents in TCM preparations is a good way for us
to explain and predict a variety of events related to the efficacy and toxicity of TCM. In the drug discovery phases, pharmacokinetics is a
key to guide medicinal chemists in the optimization process of a chemical series and to assist pharmacologists to design in vivo studies.
To explore the potentially bioactive components in TCM, it is necessary to further study the in vivo pharmacokinetic characteristics of
multiple absorbed components and find out the optical time-course behavior to providing more substantial research for new leads in
drug discovery. Pharmacokinetics screening method could provide a reliable means of prospecting natural products in the search for
new leads in drug discovery. This review summarizes the research progress of PK on TCM in the search for suitable lead compounds in
recent years. |
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