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| Possible Roles of Diet in the Etiology of Rheumatoid Arthritis: A Systematic Review |
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| DOI：10.15806/j.issn.2311-8571.2016.0021 |
| KeyWord:Diet, Rheumatoid Arthritis, Systematic review |
| Author | Institution |
| Chi Zhangabc |
a.School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon , Hong Kong
b.Hong Kong Chinese Medicine Clinical study Center, Hong Kong Baptist University, Kowloon Tong, Kowloon , Hong Kong
c.Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Nanxiaojie, Beijing , China |
| Ka-Miu Chana |
a.School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon , Hong Kong |
| Ai-Ping Luab* |
a.School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon , Hong Kong
b.Hong Kong Chinese Medicine Clinical study Center, Hong Kong Baptist University, Kowloon Tong, Kowloon , Hong Kong |
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| Abstract: |
| Background: There is a growing interest in the possible role of diet in the prevention of rheumatoid arthritis (RA). However, the evidence for
diet having a role in the etiology of RA is inconsistent, sometimes conflicting.
Objective: To critically appraise the literature to pool the results of studies to clarify the relation between diet risk and RA.
Methods: We performed a systematic review using guideline-recommended methodology to evaluate the association between pre-illness diet
or diet pattern and the risk of subsequent RA diagnosis.
Results: A total of 25 studies met the inclusion criteria. They include 13 cohort studies, 10 case-control studies and 2 nested case-control
studies, with a total of 1279810 participants. There were new evidences of a protective effect of long term consumption of alcohol. High
sodium intake was associated with an increased risk of RA. Fish intake has consistently been shown to have no effect on the development of
RA. Mediterranean diet pattern, Vitamin D intake, and the consumption of long-chain omega-3 acids were not associated with an increased/
decreased risk of RA in every two studies. There were non-statistically significant association between RA and sugar-sweetened soda, red meat,
vegetable and fruits in each single study. The association between coffee, tea and RA was consistent, and here exists an inverse relationship
between olive oil and RA. Due to the heterogeneity of study designs and analyses, the results could not be pooled.
Conclusion: The results of this SR indicate that alcohol consumption and sodium intake may be associated with RA risk, especially evidence
from recent studies. Because of some discordant results, the debate continues on whether some other dietary intakes increase or decrease
RA risk. |
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