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| Medulla Oblongata Mechanism of Inhibitory Effect ofThermal Stimulation to Nociceptive ColorectalDistention in Rats |
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| DOI：10.15806/j.issn.2311-8571.2016.0022 |
| KeyWord:Thermal stimulation, Subnucleus Reticularis Dorsalis, Stimulus Parameter
Received 29 |
| Author | Institution |
| Liang Li |
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing , China |
| Pei-Jing Rong |
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing , China |
| Xin-Yan Gao |
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing , China |
| Hui Ben |
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing , China |
| Hong Cai |
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing , China |
| Bing Zhu* |
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing |
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| Abstract: |
| Objective: To discuss mechanism of moxibustion (thermal stimulation) effect and best moxibustion stimulus parameter.
Methods: Experiments were performed on 48 male Sprague-Dawley rats. Unit discharges from individual single neuron were recorded
extracellularly with glass-microelectrode in Subnucleus Reticularis Dorsalis (SRD). Visceral-intrusive stimulation is done by colorectal
distension. Thermal stimulation with different temperature (40°C, 42°C, 44°C, 46°C, 48°C, 50°C, 52°C) and different stimulus area (diameter of
circle : 1.0 cm, 1.5 cm, 2.0 cm, 2.5 cm, 3.0 cm, 3.5 cm, 4.0cm) was applied around RN12 during nociceptive colorectal distension.
Results: SRD neurons could be activated by visceral stimulation within noxious range. Under low temperature of stimulus, especially under
45°C of pain threshold to ordinary people, visceral nociceptive afferent facilitated thermal stimulus from the body surface. While after thermal
stimulation reached a harmful degree, the thermal stimulus will inhibit visceral nociceptive afferent. Moreover, statistics show that the higher
the temperature is, the smaller the size of stimulation area is needed, and they correlate with each other negatively.
Conclusion: Visceral nociception could be inhibited by somatic thermal stimulation with specific parameter at medulla level. According to
our finding, best thermal stimulation temperature is around 48°C and the best size of stimulation area is around 3.14-7.07cm2 (with 2.0-3.0cm
diameter). |
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