|
| The Anticonvulsant Effect of Transcutaneous AuricularVagus Nerve Stimulation is Associated with Balancingthe Autonomic Dysfunction in Rats |
| |
| View Full Text View/Add Comment Download reader |
| DOI：10.15806/j.issn.2311-8571.2016.0023 |
| KeyWord:Transcutaneous auricular vagus nerve stimulation, Epilepsy, Heart rate variability, EEG |
| Author | Institution |
| Wei He |
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing , China |
| Xiao-Yu Wang |
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing , China |
| Hong Shi |
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing , China |
| Yang-Shuai Su |
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing , China |
| Xiang-Hong Jing |
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing , China |
| Bing Zhu* |
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing , China |
|
| Hits: 1546 |
| Download times: 2610 |
| Abstract: |
| Objective: The present study aims to investigate whether the anticonvulsant effect of transcutaneous auricular vagus nerve stimulation is
associated with balancing the autonomic dysfunction in rats.
Methods: Healthy adult male Sprague-Dawley rats were anesthetized with an intraperitoneal injection of 10% urethane. Seizures were evoked
by intraperitoneal injection of pentylenetetrazol (PTZ, 60 mg/kg). Femoral vein catheterization was performed for injection of sympathetic
agonist and antagonists. Bipolar globe silver electrodes were utilized for epidural EEG recording. Three needles were inserted separately in
subcutaneous muscles of left anterior limb, right anterior limb, and left hind limb to record ECG signals. ta-VNS was performed at auricular
concha.
Results: In comparison with preictal state, the mean heart rate (HR) increased slightly during epileptic seizures (P<0.05). In comparison with
ictal state, the mean HR decreased a little at postictal state (P<0.05). When continuous epileptic seizures in EEG traces occurred (in ictal state),
vein injection of propranolol hydrochloride (sympathetic antagonist) suppressed the epileptic seizures. When epileptic seizures occurred rarely
(in postictal state), vein injection of adrenaline hydrochloride (sympathetic agonist) exacerbated the epileptic seizures. In comparison with prestimulation,
the integral of EEG traces after ta-VNS decreased (P<0.05), the mean HR decreased (P<0.05), and the high power (HF) of HRV
increased (P<0.05) after ta-VNS.
Conclusion: The results showed that autonomic dysfunction occurred in epileptic rats characterized by enhanced sympathetic nerve activity.
Epileptic seizures in EEG traces decreased, HR decreased and HF increased after ta-VNS, which indicated that ta-VNS may suppress epileptic
seizures via balancing the autonomic dysfunction. |
| Close |
|
|
|