Four New Dicaffeoylspermidine Derivatives FromLycium barbarum

Zheng-Qun Zhou<sup>a#</sup>; Hong-Xia Fan<sup>a#</sup>; Rong-Rong He<sup>a</sup>; Wan-Yang Sun<sup>a</sup>; Jia Xiao<sup>b</sup>; Xue-Feng Bao<sup>a</sup>; Kwok-Fai So<sup>c</sup>; Xin-Sheng Yao<sup>a</sup>; Hao Gao<sup>a*</sup>

Four New Dicaffeoylspermidine Derivatives FromLycium barbarum

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DOI：10.15806/j.issn.2311-8571.2016.0028

KeyWord:Lycium barbarum, wolfberry, dicaffeoylspermidine derivatives, lycibarbarspermidines

Author	Institution
Zheng-Qun Zhou^a#	a.Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou ,People's Republic of China
Hong-Xia Fan^a#	a.Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou ,People’s Republic of China
Rong-Rong He^a	a.Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou ,People’s Republic of China
Wan-Yang Sun^a	a.Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou ,People’s Republic of China
Jia Xiao^b	b.Department of Immunobiology, Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University,Guangzhou , People's Republic of China
Xue-Feng Bao^a	a.Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou ,People's Republic of China
Kwok-Fai So^c	c.Guangdong Medical Key Laboratory of Brain Function and Diseases, GMH Institute of Central Nervous System Regeneration, Jinan University,Guangzhou , People's Republic of China
Xin-Sheng Yao^a	a.Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou ,People's Republic of China
Hao Gao^a*	a.Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou ,People's Republic of China

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Abstract:

Four new dicaffeoylspermidine derivatives, lycibarbarspermidines P–S (1–4), were isolated from the fruit of Lycium barbarum (wolfberry). The structures were determined by extensive spectroscopic (HRESIMS, 1D NMR, and 2D NMR) analyses and chemical methods. Dicaffeoylspermidine derivatives are a kind of major bioactive and characteristic constituents in wolfberry, and the discovery of 1–4 added new members of this family.