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| Evidence-based interventions of threatened miscarriage |
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| DOI：10.15806/j.issn.2311-8571.2016.0038 |
| KeyWord:Threatened miscarriage, Evidence-based, Intervention, Complementary and alternative medicine |
| Author | Institution |
| Juan Liab |
a.Department of Traditional Chinese Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou , China
b.Department of Obstetrics & Gynaecology, National Key Discipline and Clinical Base, Heilongjiang University of Chinese Medicine, Harbin , China |
| Jing-shu Gaob |
b.Department of Obstetrics & Gynaecology, National Key Discipline and Clinical Base, Heilongjiang University of Chinese Medicine, Harbin , China |
| Chi Chiu Wangc |
c.Department of Obstetrics & Gynaecology, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China |
| Ernest HY Ngd |
d.Department of Obstetrics & Gynaecology, The University of Hong Kong, Hong Kong Special Administrative Region, China |
| Xiao-ke Wub* |
b.Department of Obstetrics & Gynaecology, National Key Discipline and Clinical Base, Heilongjiang University of Chinese Medicine, Harbin , China |
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| Abstract: |
| Threatened miscarriage is the commonest complication of early pregnancy and affects about 20% of pregnancies. It presents with vaginal
bleeding with or without abdominal cramps. Increasing age of women, smoking, obesity or polycystic ovary syndrome (PCOS) and a previous
history of miscarriage are risk factors for threatened miscarriage. The pathophysiology has been associated with changes in levels of cytokines
or maternal immune dysfunction. Clinical history and examination, maternal serum biochemistry and ultrasound findings are important to
determine the treatment options and provide valuable information for the prognosis. Bed rest is the commonest advice, but there is little
evidence of its value. Other options include progesterone, human chorionic gonadotropin (HCG) and muscle relaxants. The complementary
and alternative medicine (CAM) therapies such as acupuncture and Chinese herbs have also been tried. There is some evidence from clinical
studies indicating that CAM therapies may reduce the rate of miscarriage, but the quality of studies is poor. Thus, further double-blind,
randomized-controlled trials are necessary to confirm its effectiveness, especially acupuncture and Chinese herbs. |
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