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| Systems response profiles to two Rehmanniae Radixformulae in metabolic syndrome patients |
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| DOI：10.15806/j.issn.2311-8571.2016.0044 |
| KeyWord:Systems biology, Metabolic syndrome, Chinese medicine diagnosis, Metabolomics, Rehmanniae Radix formula |
| Author | Institution |
| Jun-Zeng Fuab |
a.Division of Analytical Biosciences, LACDR, Leiden University, 2333 CC, Leiden, The Netherlands
b.Sino-Dutch Center for Preventive and Personalized Medicine, 3700 AJ, Zeist, The Netherlands |
| Herman A. van Wietmarschenbc |
b.Sino-Dutch Center for Preventive and Personalized Medicine, 3700 AJ, Zeist, The Netherlands
c.Louis Bolk Institute, Hoofdstraat 24, 3972 LA, Driebergen, The Netherlands |
| Jan van der Greefabd |
a.Division of Analytical Biosciences, LACDR, Leiden University, 2333 CC, Leiden, The Netherlands
b.Sino-Dutch Center for Preventive and Personalized Medicine, 3700 AJ, Zeist, The Netherlands
d.SU BioMedicine, Utrechtseweg, 3700 AJ, Zeist, The Netherlands |
| Yan Schroënbe |
b.Sino-Dutch Center for Preventive and Personalized Medicine, 3700 AJ, Zeist, The Netherlands
e.Oxrider, Education and Research, Hilvarenbeek, The Netherlands |
| Mei Wangabd |
a.Division of Analytical Biosciences, LACDR, Leiden University, 2333 CC, Leiden, The Netherlands
b.Sino-Dutch Center for Preventive and Personalized Medicine, 3700 AJ, Zeist, The Netherlands
d.SU BioMedicine, Utrechtseweg, 3700 AJ, Zeist, The Netherlands |
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| Abstract: |
| Objective: To explore the effects of two Rehmanniae Radix formulae in patients with metabolic syndrome (MetS), a randomized controlled
study was conducted.
Methods: MetS patients were randomly assigned to receive either a classic Rehmanniae Six Formula (R6, or ‘Liu Wei Di Huang Wan’) or a novel multi-herbal Rehmanniae Radix containing formula SUB889 for 8 weeks. Western medicine related clinical parameters, Chinese
medicine defined symptoms and syndromes as well as metabolomic profiles were evaluated at different time points.
Results: R6 (n = 20) and SUB889 (n = 20) showed similar effects on MetS regarding the improvement of clinical parameters (waist
circumference, body mass index, LDL-cholesterol, systolic blood pressure) and Qi/Yin deficiency (p < 0.05). Decreased levels of cholesteryl
esters, phosphatidylcholines, triglycerides and sphingomyelins were found in the R6 group, while SUB889 formula resulted in increased levels
of tricarboxylic acid cycle and glucose metabolism intermediates (malate, fumarate and pyruvate).
Conclusions: R6 and SUB889 have similar effects on the treatment of MetS by improving Chinese medicine and Western medicine defined
clinical outcomes. R6 is more effective in improving lipid profiles compared to SUB889. The exact mechanisms of the two formulae on MetS
remain to be elucidated. |
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