|
| The Effects of Different Compatibilities of Qing’e Formulaon Scopolamine‑induced Learning and Memory Impairmentin the Mouse |
| |
| View Full Text View/Add Comment Download reader |
| DOI：10.4103/wjtcm.wjtcm_8_17 |
| KeyWord:Acetylcholinesterase, brain‑derived factor, Learning and memory, Qing’e formula |
| Author | Institution |
| Xiao‑Ping Zhenga |
a.School of Pharmacy, Lanzhou University, Lanzhou |
| Fang‑Di Hua |
a.School of Pharmacy, Lanzhou University, Lanzhou |
| Li Yangbc |
b.The MOE Key Laboratory for Standardization of Chinese Medicines and the Key Laboratory for
Pharmacology of Compound Chinese Medicine of Shanghai, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, c.Research
Center for Traditional Chinese Medicine of Complexity System, Shanghai University of Traditional Chinese Medicine, Shanghai , China |
| Yu‑Ling Maa |
a.School of Pharmacy, Lanzhou University, Lanzhou |
| Bo‑Lu Suna |
a.School of Pharmacy, Lanzhou University, Lanzhou |
| Chang‑Hong Wangbc |
b.The MOE Key Laboratory for Standardization of Chinese Medicines and the Key Laboratory for
Pharmacology of Compound Chinese Medicine of Shanghai, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, c.Research
Center for Traditional Chinese Medicine of Complexity System, Shanghai University of Traditional Chinese Medicine, Shanghai , China |
| Zheng‑Tao Wangbc |
b.The MOE Key Laboratory for Standardization of Chinese Medicines and the Key Laboratory for
Pharmacology of Compound Chinese Medicine of Shanghai, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, c.Research
Center for Traditional Chinese Medicine of Complexity System, Shanghai University of Traditional Chinese Medicine, Shanghai , China |
|
| Hits: 1464 |
| Download times: 2025 |
| Abstract: |
| Background: The Qing’e formula (QEF) is a well‑known traditional Chinese prescription that has been clinically employed for treatment
of bone disease for hundreds of years. Objective: The present study aims to observe the effects of different compatibilities of QEF on the
scopolamine‑induced learning and memory impairment in the mouse, and further to explore its action mechanisms and compatibility rationality.
Materials and Methods: The learning and memory alterations in the mouse were evaluated using the step‑down test and Morris water
maze (MWM) test; the acetylcholinesterase (AChE) activity and brain‑derived neurotrophic factor (BDNF) expression in the hippocampus
were measured using colorimetric method or immunohistochemistry. Results: The results showed that different compatibilities of QEF
significantly prolonged latency in the step‑down test, shortened escape latency in the navigation test, increased the percentage of residence
time, and the percentage of swimming distance in the target quadrant in the probe trial session. In addition, our results also found that different
compatibilities of QEF remarkably inhibited AChE activity and increased BDNF expression in the hippocampus of mice. What’s more, the
group after being treated with whole recipe (QF) showed the highest level of improvement. Conclusions: These findings not only suggest
that QEF may effectively ameliorate cognitive deficits through inhibiting AChE activity and increasing BDNF expression in the hippocampus
but also elucidate the rationality of QEF |
| Close |
|
|
|