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| Research Progress on the Intervening Effects of Active Components of Chinese Herbs on Amyloid-Beta-Induced Injury of Neural Cells |
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| DOI：10.4103/wjtcm.wjtcm_11_19 |
| KeyWord:Alzheimer’s disease, amyloid-beta cascade reaction, monomer composition, traditional Chinese medicine, β-amyloid |
| Author | Institution |
| Hang-Xuan Wuabc |
a.Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica, Guangxi University of Chinese Medicine; b.Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, Guangxi University of Chinese Medicine; c.Faculty of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Guangxi, China |
| Er-Wei Haoab |
a.Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica, Guangxi University of Chinese Medicine; b.Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, Guangxi University of Chinese Medicine; |
| Zheng-Cai Duab |
a.Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica, Guangxi University of Chinese Medicine; b.Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, Guangxi University of Chinese Medicine; |
| Jian-Feng Qinab |
a.Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica, Guangxi University of Chinese Medicine; b.Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, Guangxi University of Chinese Medicine; |
| Wei Weiab |
a.Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica, Guangxi University of Chinese Medicine; b.Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, Guangxi University of Chinese Medicine; |
| Xiang-Long Panab |
a.Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica, Guangxi University of Chinese Medicine; b.Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, Guangxi University of Chinese Medicine; |
| Jin-Ling Xieab |
a.Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica, Guangxi University of Chinese Medicine; b.Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, Guangxi University of Chinese Medicine; |
| Xiao-Tao Houabc |
a.Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica, Guangxi University of Chinese Medicine; b.Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, Guangxi University of Chinese Medicine; c.Faculty of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Guangxi, China |
| Jia-Gang Dengab |
a.Guangxi Key Laboratory of Efficacy Study on Chinese MateriaMedica, Guangxi University of Chinese Medicine; b.Guangxi Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues, Guangxi University of Chinese Medicine; |
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| Abstract: |
| Alzheimer’s disease is a common clinical central nervous system degenerative disease. From 1906, it has not yet been clearly revealed the
pathogenesis, and there are no clinically safe and effective drugs. Amyloid-beta (Aβ) cascade reaction theory is currently recognized as the
pathogenesis. Aβ deposition of neurotoxicity is an important part of the pathogenesis. There are Aβ‑induced inflammation of the central nervous
and oxidative stress-induced apoptosis induced by a variety of ways leading to neuronal dysfunction and death. This article summarizes the
active ingredients of traditional Chinese medicine that has a protective effect on Aβ toxicity in recent years. Traditional Chinese medicine
mainly through the antiapoptosis, antioxidation, and anti‑inflammatory reduces Aβ production and deposition of Aβ on the protection of
nerve cell injury. |
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