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Effect of Yinqi Ointment on Wound Morphology and GrowthFactor in Treating Diabetic Foot Ulcer |
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DOI:10.4103/wjtcm.wjtcm_6_19 |
KeyWord:Diabetic foot ulcer, growth factor, wound healing, Yinqi ointment |
Author | Institution |
Ya-Li Liu a |
a.Department of Peripheral Vascular, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing, China |
You-Shan Lia |
a.Department of Peripheral Vascular, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing, China |
Yu-Qing Dua |
a.Department of Peripheral Vascular, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing, China |
Shuang Dai b |
b.Department of Orthopedics, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing, China |
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Abstract: |
Objective: To investigate the effect of Yinqi ointment on wound morphology and growth factor in treating diabetic foot ulcer (DFU).
Methods: From December 2016 to December 2017, 92 cases of DFU with deficiency of both Qi and Yin syndrome were randomly divided into
treatment group and control group (44 cases in each group). The treatment group was treated with Yinqi ointment, while the control group was
treated with mupirocin ointment. After 4 weeks of treatment, the ulcer healing effect, ulcer area, granulation tissue, epithelial tissue coverage,
pain score, and dynamic analysis of vascular endothelial growth factor (VEGF), epidermis growth factor (EGF), and basic fibroblast growth
factor (bFGF) in local granulation tissue were statistically analyzed before and after treatment in both groups. Results: The total effective rate
was 88.37% in the treatment group and 74.42% in the control group. The wound reduction rate, epithelial tissue coverage rate, granulation
tissue growth rate, and local pain relief rate in the treatment group were significantly superior to those in the control group (P < 0.05). Through
the local granulation detection, the treatment group and the control group have increased VEGF, EGF, and bFGF, but the treatment group
increased the role of growth factor than the control group. Conclusion: Yinqi ointment can promote the healing of DFU, and its mechanism
may be related to the increase of the content of growth factor in granulation tissue. |
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