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| Active Compounds and Molecular Targets of Chinese Herbal Medicine for Neurogenesis in Stroke Treatment: Implication for Cross Talk between Traditional Chinese Medicine and Biomedical Sciences |
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| DOI：10.4103/wjtcm.wjtcm_14_19 |
| KeyWord:Chinese herbal medicine, neurogenesis, stroke |
| Author | Institution |
| Xi Chenabc |
a.School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR;b.Department of Core Facility, The People’s Hospital
of Bao‑an;c.Department of Core Facility, The 8th People’s Hospital of Shenzhen, The Affiliated Baoan Hospital of Southern Medical University |
| Han-Sen Chena |
a.School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR |
| Cheng Pengd |
d.College of Medical Technology and School of Pharmacy, Chengdu University of Traditional Chinese Medicine, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Sichuan Province and Ministry of Science and Technology, Chengdu, China |
| Jian-Gang Shenab |
a.School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR;b.Department of Core Facility, The People’s Hospital
of Bao‑an |
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| Abstract: |
| Neural stem/progenitor cells (NSCs) could be attractive therapeutic targets for promoting adult neurogenesis, brain plasticity, and repair in
stroke and neurodegenerative diseases, raising great potentials for regeneration therapy. In adult ischemic brains, NSCs have limited capacities
of growth, differentiation, and generating new neurons for repairing the damaged central nervous system. However, the spontaneous brain repair
seems to be insufficient to recover neurological deficits in most stroke cases. To overcome those problems, pharmacological manipulations
targeting on endogenous NSCs or transplanted stem cells could be a promoting strategy for regeneration therapy. Chinese herbal medicine
has great potentials for developing novel therapeutic strategies for adult neurogenesis and brain repair in poststroke treatment. Chinese herbal
medicine has a long history for poststroke treatment. Recent studies create great opportunity for drug discovery for promoting neurogenesis
and improving the recovery of neurological functions in poststroke treatment. Many active compounds or extracts from medicinal herbs have
shown promising effects on regulating proliferation, self-renewal and differentiation of NSCs, and promoting neural network formation as
well as neurological functional recovery with in vitro and in vivo experimental evidence. Therefore, targeting neural stem/progenitor cells
can be an important opportunity for the studies of Traditional Chinese Medicine in regeneration medicine. Due to the complex interactions of
herbal ingredients in network regulation, huge challenge remains to be resolved for further study. |
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