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| A Study on the Mechanism of the Protective Effect of GuangeFang on Sepsis‑Associated Acute Kidney Injury |
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| DOI：10.4103/2311-8571.328618 |
| KeyWord:GuangeFang, Janus kinase 2, mammalian target of rapamycin, sepsis-associated acute kidney injury |
| Author | Institution |
| Shuo Lia |
a.Intensive Care Unit, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China |
| Qing‑Quan Liua |
a.Intensive Care Unit, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China |
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| Abstract: |
| Objective: The objective of this study was to explore the mechanism of Guan Gefang (GGF) ; raw rhubarb 30 g, cassia arboreal 30 g, raw
oyster 30 g, ground elm 60 g, and dandelion 30 g) kidney protection. Materials and Methods: Thirty‑six Sprague Dawley rats were randomly
divided into a control group (Group N), a sepsis control group (Group S), and a sepsis + GGF group (Group G). For Group N, 8 ml/kg 0.9%
NaCl was used as an enema; for Group S, cecal ligation and puncture (CLP) method was used for modeling and 8 ml/kg 0.9% NaCl was used
as an enema; and Group G, CLP was used for modeling and 8 ml/kg GGF was used as an enema. All of the enemas were applied once daily
for 4 days. The indices of serum creatinine (SCr), blood urea nitrogen (BUN), uric acid (UA), mammalian target of rapamycin (mTOR), Janus
kinase 2 (JAK2) were compared across each group. Results: Compared to Group S, Group G had lower levels of SCr, BUN, and UA(P < 0.05),
while the activities of mTOR and JAK2 were significantly inhibited. Conclusion: GGF may have inhibited the JAK2 or mTOR signaling
pathways to protect the rats’ kidneys, which had sepsis-associated acute kidney injury. |
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